Home
Products
Lactacystin
| Product Name | Lactacystin |
| Price: | Inquiry |
| Catalog No.: | CN01823 |
| CAS No.: | 133343-34-7 |
| Molecular Formula: | C15H24N2O7S |
| Molecular Weight: | 376.43 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | From Streptomyces sp. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: |
| Contact us | |
|---|---|
| First Name: | |
| Last Name: | |
| E-mail: | |
| Question: | |
| Description | Lactacystin, an antibiotic Streptomyces spp. metabolite, is a potent and selective proteasome inhibitor with an IC50 of 4.8 μM for 20S proteasome. Lactacystin also inhibits the lysosomal enzyme cathepsin A[1]. Lactacystin inhibits cell growth and induces neurite outgrowth[2]. |
| Target | IC50: 4.8 μM (proteasome)[1] |
| In Vivo | Lactacystin (microinjection; 2 µg) induces a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice[2]. Animal Model: Male C57Bl/6RccHsd mice with 8-9 weeks (young) and 12-14 months (adult) old[2] Dosage: 2 µg Administration: Microinjection Result: Induced a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 714.9±60.0 °C at 760 mmHg |
| Flash Point | 386.1±32.9 °C |
| Exact Mass | 376.130432 |
| PSA | 178.33000 |
| LogP | -1.10 |
| Vapour Pressure | 0.0±5.2 mmHg at 25°C |
| Storage condition | −20°C |