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Bakkenolide B
| Product Name | Bakkenolide B |
| Price: | Inquiry |
| Catalog No.: | CN09192 |
| CAS No.: | 18455-98-6 |
| Molecular Formula: | C22H30O6 |
| Molecular Weight: | 390.47 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The leaves of Peatasites japonicus. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Bakkenolide B is isolated from petasites japonicas leaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma[1]. |
| In Vitro | Bakkenolide B (0-100 μg/ml; pretreatment 30 mins) inhibits antigen-induced β-hexosamidase release from RBL2H3 mast cells in a concentration-dependent manner[1]. Bakkenolide B (0-10 μg/ml; 1 h later stimulated with LPS) strongly inhibits the gene inductions of inducible nitric oxide synthase and cyclooxygenase-2 in a concentration-dependent manner in mouse peritoneal macrophages[1]. Western Blot Analysis[1] Cell Line: Mouse peritoneal macrophages Concentration: 0 μg/ml; 1 μg/ml; 3 μg/ml; 5 μg/ml; 10 μg/ml Incubation Time: 1 h later stimulated with LPS Result: Decreased iNOS and cox-2 protein expression. |
| In Vivo | Bakkenolide B (intraperitoneal injection; 1 mg/ml; 1 h before ovalbumin nebulization on days 28, 29, and 30) strongly inhibits the accumulation of eosinophils, macrophages, and lymphocytes to bronchoalveolar lavage fluid (BALF) in ovalbumin-induced asthma mice[1]. Animal Model: Ovalbumin-induced asthma mice[1] Dosage: 1 mg/ml Administration: Intraperitoneal injection; 1 h before ovalbumin nebulization on days 28, 29, and 30 Result: Exhibited anti-allergic effects in mice. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 503.0±50.0 °C at 760 mmHg |
| Flash Point | 217.1±30.2 °C |
| Exact Mass | 390.204254 |
| LogP | 4.07 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |