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Zedoarondiol
| Product Name | Zedoarondiol |
| Price: | Inquiry |
| Catalog No.: | CN09305 |
| CAS No.: | 98644-24-7 |
| Molecular Formula: | C15H24O3 |
| Molecular Weight: | 252.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Solid |
| Source: | The rhizomes of Curcuma phaeocaulis. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC(=C1C[C@H]2[C@H]([C@@](CC1=O)(C)O)CC[C@@]2(C)O)C |
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| Description | Zedoarondiol, a sesquiterpene lactone compound, with antioxidant and anti-inflammatory activity. Zedoarondiol can be used for atherosclerosis research[1][2]. |
| In Vitro | Zedoarondiol (5-20 μg/mL) attenuates HUVECs injury, up-regulated SOD activity, suppressed formation of MDA and ROS, and secretion and protein expression of IL-1β, TNF-α, and MCP-1 in injured HUVECs induced by oxidized low-density lipoprotein (ox-LDL)[1]. Zedoarondiol induces nuclear Nrf2 translocation from cytoplasm into nucleus and up-regulated expression of HO-1, NQO1, and Nrf2 in nucleus[1]. Zedoarondiol suppresses PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation and DNA synthesis, and induces cell cycle arrest in G0/G1 phase. In addition, Zedoarondiol activates AMPK and ACC, inhibited the phosphorylation of mTOR and p70S6K, increases the expression of p53 and p21, and decreases the expression of CDK2 and cyclin E[1]. |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 396.8±42.0 °C at 760 mmHg |
| Flash Point | 207.9±24.4 °C |
| Exact Mass | 252.172546 |
| LogP | 1.63 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |